Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2

Abstract Targeting proteins to their final cellular destination requires transport mechanisms and nearly all lysosomal enzymes reach the lysosome via the mannose-6-phosphate receptor pathway. One of the few known exceptions is the enzyme β-glucocerebrosidase (GCase) that requires the lysosomal integ...

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Main Authors: Jan Philipp Dobert, Jan-Hannes Schäfer, Thomas Dal Maso, Priyadarshini Ravindran, Dustin J. E. Huard, Eileen Socher, Lisa A. Schildmeyer, Raquel L. Lieberman, Wim Versées, Arne Moeller, Friederike Zunke, Philipp Arnold
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58340-1
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https://doi.org/10.1038/s41467-025-58340-1

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