Synthesis of Antimicrobial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies

Synthesis of Antimicrobial Norlabdane Compounds with Rearranged Cycle B and Molecular Docking Studies

The synthesis of tetra- and pentanorlabdane compounds with rearranged cycle B based on commercially available (+)-sclareolide is reported. Desired compounds were prepared from intermediate ketones via Baeyer–Villiger oxidation. The structures of synthesized compounds were confirmed by spectral IR, 1...

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Bibliographic Details
Main Authors: Alexandru Ciocarlan, Lidia Lungu, Sergiu Shova, Nicoleta Vornicu, Natalia Bolocan, Veaceslav Kulcitki, Aculina Aricu
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
(+)-sclareolide
methyl 7-oxo-13,14,15,16-tetranorlabd-8-en-12-oate
7-oxo-12,13,14,15,16-pentanorlabd-8-ene
Baeyer-Villiger oxidation
antimicrobial activity
DFT
Online Access:https://www.mdpi.com/1420-3049/29/23/5714
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