Transfer learning drives automatic HER2 scoring on HE-stained WSIs for breast cancer: a multi-cohort study

Transfer learning drives automatic HER2 scoring on HE-stained WSIs for breast cancer: a multi-cohort study

Abstract Background Streamlining the clinical procedure of human epidermal growth factor receptor 2 (HER2) examination is challenging. Previous studies neglected the intra-class variability within both HER2-positive and -negative groups and lacked multi-cohort validation. To address this deficiency,...

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Main Authors: Xiaoping Li, Zhiquan Lin, Chaoran Qiu, Yiwen Zhang, Chuqian Lei, Shaofei Shen, Weibin Zhang, Chan Lai, Weiwen Li, Hui Huang, Tian Qiu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer
HER2 scoring
Whole slide images
Multi-cohort
Transfer learning
Online Access:https://doi.org/10.1186/s13058-025-02008-7
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https://doi.org/10.1186/s13058-025-02008-7

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