Characterization and comparative profiling of piRNAs in serum biopsies of pediatric Wilms tumor patients

Characterization and comparative profiling of piRNAs in serum biopsies of pediatric Wilms tumor patients

Abstract Piwi-interacting RNAs (piRNAs) are small non-coding RNAs involved in transposon silencing and linked to cancer progression. However, their role in Wilms tumors (WT) remains unexplored. We conducted a thorough analysis and characterization of piRNAs in serum liquid biopsies of WT patients. O...

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Bibliographic Details
Main Authors: Fatma S. Mohamed, Deena Jalal, Youssef M. Fadel, Samir F. El-Mashtoly, Wael Z. Khaled, Ahmed A. Sayed, Mohamed A. Ghazy
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cancer Cell International
Subjects:
PiRNAome profiling
Non-transposon-related PiRNAs
Non-germline functions
Diagnostic potential
Blood-based biomarkers
Wilms tumor
Online Access:https://doi.org/10.1186/s12935-025-03780-4
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https://doi.org/10.1186/s12935-025-03780-4

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