Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation

Molecular mechanisms of the Xiao-chai-hu-tang on chronic stress-induced colorectal cancer growth based on an integrated network pharmacology and RNA sequencing approach with experimental validation

Abstract Background Chronic stress is a risk factor for the development of colorectal cancer (CRC). Xiao-chai-hu-tang (XCHT) is a traditional Chinese medicine prescription and has been widely used to treat chronic stress-related diseases and cancer. However, its role in chronic stress-induced CRC re...

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Bibliographic Details
Main Authors: Wang Yao, Dong-Ming Hua, Ying-Ru Zhang, Yi-Yang Zhao, Ying Feng, Zhao-Zhou Zhang, Zhong-Ya Ni, Hai-dong Guo, Yun-Feng Guan, Yan Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Chronic stress
Colorectal cancer
Network pharmacology
IL-6/JAK2/STAT3
Glycolysis
Xiao-Chai-Hu-Tang
Online Access:https://doi.org/10.1186/s12906-025-04860-8
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https://doi.org/10.1186/s12906-025-04860-8

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