A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation

A secreted Tapasin isoform impairs cytotoxic T lymphocyte recognition by disrupting exogenous MHC class I antigen presentation

Endogenous and exogenous antigen processing and presentation through the MHC class I peptide-loading complex (PLC) are essential for initiating cytotoxic T lymphocyte responses against pathogens and tumors. Tapasin, a key component of the PLC, is produced in multiple isoforms through alternative spl...

Full description

Saved in:
Bibliographic Details
Main Authors: Robyn P. Seipp, Guillaume Hoeffel, Alexander R. Moise, Siri Lok, Anne-Claire Ripoche, Concepción Marañón, Anne Hosmalin, Wilfred A. Jefferies
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
antigen presentation/processing
MHC class I
dendritic cells
cytotoxic T cells
Tapasin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1525136/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1525136/full

Similar Items