Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination
Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibrom...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/185730 |
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| author | Tine Gregersen Nanna Holt Henning Gronbaek Ida Vogel Lars J. Jørgensen Klaus Krogh |
| author_facet | Tine Gregersen Nanna Holt Henning Gronbaek Ida Vogel Lars J. Jørgensen Klaus Krogh |
| author_sort | Tine Gregersen |
| collection | DOAJ |
| description | Neuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids. |
| format | Article |
| id | doaj-art-3d60523391e545538248e047ac56d53e |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-3d60523391e545538248e047ac56d53e2025-02-03T05:52:59ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362012-01-01201210.1155/2012/185730185730Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare CombinationTine Gregersen0Nanna Holt1Henning Gronbaek2Ida Vogel3Lars J. Jørgensen4Klaus Krogh5Department of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, DenmarkDepartment of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, DenmarkDepartment of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, DenmarkDepartment of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21 C, 8200 Aarhus N, DenmarkInstitute of Pathology, Vendsyssel Hospital, Bispensgade 37, 9800 Hjorring, DenmarkDepartment of Medicine, Hepatology and Gastroenterology, Aarhus University Hospital, Norrebrogade 44, 8000 Aarhus C, DenmarkNeuroendocrine tumors are rare tumors primarily located in the gastrointestinal tract. Goblet cell carcinoid is a rare subgroup of neuroendocrine tumors located in the appendix. Neurofibromatosis type 1 is an autosomal dominant disorder caused by a mutation in the NF1 gene. Patients with neurofibromatosis type 1 have an increased incidence of typical neuroendocrine tumors, but it is unknown if this is the case with goblet cell carcinoids. We describe a patient with both neurofibromatosis type 1 and goblet cell carcinoid, that according to literature would occur in 0.00017 per million per year. This may suggest a previously unknown association between neurofibromatosis type 1 and goblet cell carcinoids.http://dx.doi.org/10.1155/2012/185730 |
| spellingShingle | Tine Gregersen Nanna Holt Henning Gronbaek Ida Vogel Lars J. Jørgensen Klaus Krogh Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination Case Reports in Gastrointestinal Medicine |
| title | Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination |
| title_full | Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination |
| title_fullStr | Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination |
| title_full_unstemmed | Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination |
| title_short | Goblet Cell Carcinoid in a Patient with Neurofibromatosis Type 1: A Rare Combination |
| title_sort | goblet cell carcinoid in a patient with neurofibromatosis type 1 a rare combination |
| url | http://dx.doi.org/10.1155/2012/185730 |
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