COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation

COVID-19 progression and convalescence in common variable immunodeficiency patients show dysregulated adaptive immune responses and persistent type I interferon and inflammasome activation

Abstract Common variable immunodeficiency (CVID) is the most prevalent primary immunodeficiency, marked by hypogammaglobulinemia, poor antibody responses, and increased infection susceptibility. The COVID-19 pandemic provided a unique opportunity to study the effects of prolonged viral infections on...

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Main Authors: Javier Rodríguez-Ubreva, Josep Calafell-Segura, Celia L. Calvillo, Baerbel Keller, Laura Ciudad, Louis-François Handfield, Carlos de la Calle-Fabregat, Gerard Godoy-Tena, Eduardo Andrés-León, Regina Hoo, Tarryn Porter, Elena Prigmore, Maike Hofmann, Annegrit Decker, Javier Martín, Roser Vento-Tormo, Klaus Warnatz, Esteban Ballestar
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54732-x
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https://doi.org/10.1038/s41467-024-54732-x

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