TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2

Glioblastoma (GBM) exhibits elevated TRIM22 expression correlated with tumor progression, as validated in TCGA/GEO databases. The effects of TRIM22 knockdown and overexpression on GBM proliferation were evaluated with cellular assays. TRIM22 was identified as a potential Bcl-2 activator via a ubiqui...

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Bibliographic Details
Main Authors: Jiahao Zhang, Yuning Chen, Gaosong Wang, Hui Huang, Yuankun Liu, Jin Huang, Junfei Shao, Jiantong Jiao, Chao Cheng
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Molecular & Cellular Oncology
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Online Access:https://www.tandfonline.com/doi/10.1080/23723556.2025.2518679
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