Electro-oxidative amination of benzylic C(sp³)–C(sp³) bonds in aromatic hydrocarbons

Abstract C(sp3)-C(sp3) amination represents a promising approach for synthesizing various amines, facilitating applications from late-stage scaffold hopping to the degradation of polymers and biomass. However, it remains challenging due to the inertness of the C-C bond and difficulties in controllin...

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Bibliographic Details
Main Authors: Kai-Xuan Yang, Shu-Fan He, Qinhui Wan, Tianyi Xu, Daixi Li, Kexin Liu, Wenying Ai, Tao Shen
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61017-4
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