CDX2 loss in colorectal cancer cells is associated with invasive properties and tumor budding

CDX2 loss in colorectal cancer cells is associated with invasive properties and tumor budding

Abstract In colorectal cancer (CRC), tumor buds (TB) are observed histologically as single tumor cell or small tumor cell clusters located mainly at the advancing tumor edge. TB are a marker of poor prognosis and correlate with metastatic disease in CRC patients. They often lack expression of CDX2 a...

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Bibliographic Details
Main Authors: Nils Bodmer, Kristin Uth, Rina Mehmeti, Cansaran Saygili Demir, Deborah Stroka, Nassim Ghaffari-Tabrizi-Wizsy, Alessandro Lugli, Olivier de Wever, Inti Zlobec, Mario P. Tschan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Colorectal cancer
CDX2
Tumor budding
Cell migration
EMT
Online Access:https://doi.org/10.1038/s41598-025-07278-x
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https://doi.org/10.1038/s41598-025-07278-x

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