Novel FGF21 analogues through structure-based optimization for therapeutic development

Fibroblast growth factor 21 (FGF21) plays a pivotal role in regulating metabolic processes and energy homeostasis, making it a promising therapeutic avenue for various obesity-related conditions. However, its therapeutic efficacy faces challenges due to its suboptimal pharmacokinetics and bioactivit...

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Bibliographic Details
Main Authors: Guo Yiqing, Bao Yuxuan, Chen Zhichao, Rao Zhiheng, Luo Yongde, Ye Sheng, Liu Si
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-12-01
Series:Acta Biochimica et Biophysica Sinica
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Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024227
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