Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

Isoform-specific disruption of the TP73 gene reveals a critical role for TAp73γ in tumorigenesis via leptin

TP73, a member of the p53 family, is expressed as TAp73 and ΔNp73 along with multiple C-terminal isoforms (α−η). ΔNp73 is primarily expressed in neuronal cells and necessary for neuronal development. Interestingly, while TAp73α is a tumor suppressor and predominantly expressed in normal cells, TAp73...

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Bibliographic Details
Main Authors: Xiangmudong Kong, Wensheng Yan, Wenqiang Sun, Yanhong Zhang, Hee Jung Yang, Mingyi Chen, Hongwu Chen, Ralph W de Vere White, Jin Zhang, Xinbin Chen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-08-01
Series:eLife
Subjects:
TAp73
p53
Leptin
oncogenesis
obesity
TAp73γ
Online Access:https://elifesciences.org/articles/82115
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