Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells.

Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells.

Recent reports have shown that cannabinoid 1 receptors (CB1Rs) are expressed in pancreatic β cells, where they induce cell death and cell cycle arrest by directly inhibiting insulin receptor activation. Here, we report that CB1Rs regulate the expression of the anti-apoptotic protein Bcl-2 and cell c...

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Bibliographic Details
Main Authors: Jihye Kim, Kyung Jin Lee, Jung Seok Kim, Jun Gi Rho, Jung Jae Shin, Woo Keun Song, Eun Kyung Lee, Josephine M Egan, Wook Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150981&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150981&type=printable

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