The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

The senolytic agent ABT263 ameliorates osteoporosis caused by active vitamin D insufficiency through selective clearance of senescent skeletal cells

Background/Objective: Active vitamin D insufficiency accelerates the development of osteoporosis, with senescent bone cells and the senescence-associated secretory phenotype (SASP) playing crucial roles. This study aimed to investigate whether the senolytic agent ABT263 could correct osteoporosis ca...

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Bibliographic Details
Main Authors: Cuicui Yang, Wanxin Qiao, Qi Xue, David Goltzman, Dengshun Miao, Zhan Dong
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Journal of Orthopaedic Translation
Subjects:
Cellular senescence
Osteoporosis
SASP
Senolytics
Vitamin D insufficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X24000998
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