mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice

mRNA-LNP vaccine encoding the Plasmodium vivax circumsporozoite protein is highly immunogenic and confers protection in mice

Plasmodium vivax poses significant challenges to malaria control due to its relapsing nature. This study explores the immunogenicity and efficacy of nucleoside-modified mRNA-lipid nanoparticle (LNP) vaccines targeting the P. vivax circumsporozoite protein (PvCSP). Two mRNA constructs encoding PvCSP...

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Bibliographic Details
Main Authors: Amporn Limsalakpetch, Utaiwan Kum-Arb, Kosol Yongvanitchit, Rawiwan Im-Erbsin, Ratawan Ubalee, Norman Waters, Brian A. Vesely, Hiromi Muramatsu, Drew Weissman, Ying K. Tam, Shigeto Yoshida, John Adams, Anjali Yadava, Norbert Pardi, Sathit Pichyangkul
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
mRNA vaccine
nucleoside-modification
lipid nanoparticle
P. vivax
circumsporozoite protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001994
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http://www.sciencedirect.com/science/article/pii/S2162253125001994

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