Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation

Tomatidine relieves neuronal damage in spinal cord injury by inhibiting the inflammatory responses and apoptosis through blocking the NF-κB/CXCL10 pathway activation

BackgroundSpinal cord injury (SCI) is a neurological disease characterized by high disability and mortality rates. Tomatidine, a natural steroid alkaloid, has been evidenced to have neuroprotective properties. However, the underlying mechanisms of tomatidine in treating SCI remain ambiguous. This st...

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Bibliographic Details
Main Authors: Xu Wang, Wei Huang, Hao Sun, Hua Wang, Dongxu Wang, Yongxiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
tomatidine
spinal cord injury
neuronal damage
nuclear factor-κB/C-X-C motif chemokine ligand 10 pathway
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1503925/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1503925/full

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