Simple horizontal magnetic tweezers for micromanipulation of single DNA molecules and DNA—protein complexes

Simple horizontal magnetic tweezers for micromanipulation of single DNA molecules and DNA—protein complexes

We report the development of a simple-to-implement magnetic force transducer that can apply a wide range of piconewton (pN) scale forces on single DNA molecules and DNA—protein complexes in the horizontal plane. The resulting low-noise force-extension data enable very high-resolution detection of ch...

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Bibliographic Details
Main Authors: Christopher P. McAndrew, Christopher Tyson, Joseph Zischkau, Patrick Mehl, Pamela L. Tuma, Ian L. Pegg, Abhijit Sarkar
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:BioTechniques
Subjects:
single molecule—micromanipulation
magnetic tweezers
differential measurement
magnetic trap
Online Access:https://www.future-science.com/doi/10.2144/000114369
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https://www.future-science.com/doi/10.2144/000114369

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