Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Metformin ameliorates osteoporosis by enhancing bone angiogenesis via the YAP1/TAZ-HIF1α axis

Abstract Background Osteoporosis, resulting from an imbalance between osteoclast-mediated bone resorption and osteoblast-mediated bone formation, affects millions globally. Recent studies have identified type H vessels (CD31hiEMCNhi) as a specialized subset of bone blood vessels that positively regu...

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Main Authors: Hao Yin, Zhe Ruan, Teng-Fei Wan, Zhi-Rou Lin, Chun-Yuan Chen, Zhen-Xing Wang, Jia Cao, Yi-Yi Wang, Ling Jin, Yi-Wei Liu, Guo-Qiang Zhu, Jiang-Shan Gong, Jing-Tao Zou, Yi Luo, Yin Hu, Zhao-Hui Li, Hao Luo, Yu-Qi Liu, Cheng Long, Shu-Shan Zhao, Yong Zhu, Hui Xie
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Molecular Medicine
Subjects:
Metformin
Osteoporosis
YAP1/TAZ
HIF1α
Angiogenesis
Type H vessel
Online Access:https://doi.org/10.1186/s10020-025-01169-7
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https://doi.org/10.1186/s10020-025-01169-7

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