Targeting the CXCR4/CXCL12 Axis in Cancer Therapy: Analysis of Recent Advances in the Development of Potential Anticancer Agents

Targeting the CXCR4/CXCL12 Axis in Cancer Therapy: Analysis of Recent Advances in the Development of Potential Anticancer Agents

Cancer, a leading cause of premature death, arises from genetic and epigenetic mutations that transform normal cells into tumor cells, enabling them to proliferate, evade cell death, and stimulate angiogenesis. Recent evidence indicates that chemokines are essential in tumor development, activating...

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Bibliographic Details
Main Authors: Gerardina Smaldone, Francesca Di Matteo, Roberta Castelluccio, Valeria Napolitano, Maria Rosaria Miranda, Michele Manfra, Pietro Campiglia, Vincenzo Vestuto
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Molecules
Subjects:
cancer
CXCR4/CXCL12 axis
small molecules
antitumor drugs
Online Access:https://www.mdpi.com/1420-3049/30/6/1380
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