Breast cancer patient-derived scaffolds enhance the understanding of PD-L1 regulation and T cell cytotoxicity

Breast cancer patient-derived scaffolds enhance the understanding of PD-L1 regulation and T cell cytotoxicity

Abstract Recent advances as well as obstacles for immune-based cancer treatment strategies, highlight the notable impact of patient cancer microenvironments on the immune cells and immune targets. Here, we use patient-derived scaffolds (PDS) generated from 110 primary breast cancers to monitor the i...

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Main Authors: Elena Garre, Sara Rhost, Anna Gustafsson, Louis Szeponik, Thais Fenz Araujo, Marianne Quiding-Järbrink, Khalil Helou, Anders Ståhlberg, Göran Landberg
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08054-3
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https://doi.org/10.1038/s42003-025-08054-3

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