Diminished immune cell adhesion in hypoimmune ICAM-1 knockout human pluripotent stem cells

Diminished immune cell adhesion in hypoimmune ICAM-1 knockout human pluripotent stem cells

Abstract Gene edited human pluripotent stem cells are a promising platform for developing reparative cellular therapies that evade immune rejection. Existing first-generation hypoimmune strategies have used CRISPR/Cas9 editing to modulate genes associated with adaptive immune responses, but have lar...

Full description

Saved in:
Bibliographic Details
Main Authors: Sayandeep Saha, W. John Haynes, Jiwon Seo, Natalia M. Del Rio, Elizabeth E. Young, Jue Zhang, Alexis M. Holm, Mireya Pimentel, Lauryn Flannagan, Liupei Huang, Wesley Blashka, Lydia Murphy, Merrick J. Scholz, Abigale Henrichs, Jayalaxmi Suresh Babu, John Steill, Jeremy Kratz, Ron Stewart, Timothy J. Kamp, Matthew E. Brown
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62568-2
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-025-62568-2

Similar Items