Synergistic Interaction Between <i>Justicia spicigera</i> Extract and Analgesics on the Formalin Test in Rats

Synergistic Interaction Between <i>Justicia spicigera</i> Extract and Analgesics on the Formalin Test in Rats

<b>Background:</b> Combining antinociceptive drugs with different mechanisms of action can reduce the doses and the adverse effects, with a possible increase in the antinociceptive effect. This work evaluated the antinociceptive effect of the combination of an ethanol extract of <i>...

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Main Authors: Juan Ramón Zapata-Morales, Angel Josabad Alonso-Castro, María Leonor González-Rivera, Hugo Israel González Prado, Juan Carlos Barragán-Gálvez, Araceli Hernández-Flores, María del Carmen Juárez-Vázquez, Fabiola Domínguez, Candy Carranza-Álvarez, Amaury de Jesús Pozos-Guillén, Juan F. López-Rodríguez, Patricia Aguirre-Bañuelos, Marco Antonio Ramírez-Morales
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Pharmaceuticals
Subjects:
<i>Justicia spicigera</i>
naproxen
tramadol
formalin test
isobolographic analysis
synergism
Online Access:https://www.mdpi.com/1424-8247/18/2/187
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