Hyperoside mitigates amphotericin B-induced nephrotoxicity in HK-2 cells via bioenergetic and oxidative stress modulation

Hyperoside mitigates amphotericin B-induced nephrotoxicity in HK-2 cells via bioenergetic and oxidative stress modulation

Abstract Amphotericin B (Amp-B/FZ), a first-line antifungal, is limited by dose-dependent nephrotoxicity. This study investigated the protective effects of hyperoside (HP), a dietary flavonoid, against FZ-induced renal toxicity in human proximal tubular (HK-2) cells. Molecular docking revealed stron...

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Main Authors: Ekramy M. Elmorsy, Huda A. Al Doghaither, Ayat B. Al-Ghafari, Badriah Abdullah Hifni, Najlaa M.M. Jawad, Noor A. Hakim, Manal S. Fawzy, Nagwa M. Aly
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Pharmacology and Toxicology
Subjects:
Amphotericin B
Fungizone
Hyperoside
Nephrotoxicity
Bioenergetic disruption
Online Access:https://doi.org/10.1186/s40360-025-00985-1
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https://doi.org/10.1186/s40360-025-00985-1

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