Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines

Haplotype-resolved assemblies of the MHC region in five widely used tumor cell lines

The major histocompatibility complex (MHC) region plays a crucial role in immune function and is implicated in various diseases and cancer immunoediting. However, its high polymorphism poses challenges for accurate genetic profiling using conventional reference genomes. Here, we present high-quality...

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Main Authors: Haozhe Yuan, Mengping Jiang, Xingyu Xu, Jialiang Zhu, Shulong Dong, Weida Meng, Dandan Zhang, Jiakang Ma, Yicheng Lin, Ziqiang Chen, Shaoyang Sun, Wenqing Qiu, Yun Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-09-01
Series:Genes and Diseases
Subjects:
Cell lines
CRISPR-Cas9
Haplotype-resolved assembly
MHC
Targeted sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304225000923
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http://www.sciencedirect.com/science/article/pii/S2352304225000923

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