Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease

Anxiety-like behavior and altered hippocampal activity in a transgenic mouse model of Fabry disease

Background: Fabry disease (FD) patients are known to be at high risk of developing neuropsychiatric symptoms such as anxiety, depression and cognitive deficits. Despite this, they are underdiagnosed and inadequately treated. It is unknown whether these symptoms arise from pathological glycosphingoli...

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Bibliographic Details
Main Authors: Kai Kummer, Jeiny Luna Choconta, Marie-Luise Edenhofer, Archana Bajpai, Gopuraja Dharmalingam, Theodora Kalpachidou, David A. Collier, Michaela Kress
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
Fabry disease
Globotriaosylceramide
hippocampus
Single-cell sequencing
Electrophysiology
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000130
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