Standardized Workflow and Analytical Validation of Cell-Free DNA Extraction for Liquid Biopsy Using a Magnetic Bead-Based Cartridge System

Standardized Workflow and Analytical Validation of Cell-Free DNA Extraction for Liquid Biopsy Using a Magnetic Bead-Based Cartridge System

Circulating cell-free DNA (cfDNA) is an important biomarker for various cancer types, enabling a non-invasive testing approach. However, pre-analytical variables, including sample collection, tube type, processing conditions, and extraction methods, can significantly impact the yield, integrity, and...

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Bibliographic Details
Main Authors: Shivaprasad H. Sathyanarayana, Sarah B. Spracklin, Sophie J. Deharvengt, Donald C. Green, Margery D. Instasi, Torrey L. Gallagher, Parth S. Shah, Gregory J. Tsongalis
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
cell-free DNA
liquid biopsy
cfDNA extraction
TapeStation
reference materials
cancer detection
Online Access:https://www.mdpi.com/2073-4409/14/14/1062
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