TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Abstract The heterogeneous nature of colorectal cancer (CRC) complicates prognosis and is suggested to be a determining factor in the efficacy of adjuvant therapy for individual patients. Based on gene expression profiling, CRC is currently classified into four consensus molecular subtypes (CMSs), c...

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Main Authors: Evelyn Fessler, Jarno Drost, Sander R van Hooff, Janneke F Linnekamp, Xin Wang, Marnix Jansen, Felipe De Sousa E Melo, Pramudita R Prasetyanti, Joep EG IJspeert, Marek Franitza, Peter Nürnberg, Carel JM van Noesel, Evelien Dekker, Louis Vermeulen, Hans Clevers, Jan Paul Medema
Format: Article
Language:English
Published: Springer Nature 2016-05-01
Series:EMBO Molecular Medicine
Subjects:
cancer subtypes
colorectal cancer
epithelial–mesenchymal transition
sessile serrated adenoma
transforming growth factor beta (TGFβ)
Online Access:https://doi.org/10.15252/emmm.201606184
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https://doi.org/10.15252/emmm.201606184

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