Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors

Association between somatic microsatellite instability, hypermutation status, and specific T cell subsets in colorectal cancer tumors

BackgroundMicrosatellite instability-high (MSI-high) tumors comprise ~15% of sporadic colorectal cancers (CRC) and are associated with elevated T cell infiltration. However, the universality of this response across T cell subtypes with distinct functions is unknown.MethodsIncluding 1,236 CRC tumors...

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Main Authors: Claire E. Thomas, Yasutoshi Takashima, Evertine Wesselink, Tomotaka Ugai, Robert S. Steinfelder, Daniel D. Buchanan, Conghui Qu, Li Hsu, Andressa Dias Costa, Steven Gallinger, Robert C. Grant, Jeroen R. Huyghe, Sushma S. Thomas, Shuji Ogino, Amanda I. Phipps, Jonathan A. Nowak, Ulrike Peters
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
microsatellite instability
hypermutation
DNA mismatch repair
T cells
epithelial
stromal
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505896/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1505896/full

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