The RMaP challenge of predicting RNA modifications by nanopore sequencing

The RMaP challenge of predicting RNA modifications by nanopore sequencing

Abstract The field of epitranscriptomics is undergoing a technology-driven revolution. During past decades, RNA modifications like N6-methyladenosine (m6A), pseudouridine (ψ), and 5-methylcytosine (m5C) became acknowledged for playing critical roles in cellular processes. Direct RNA sequencing by Ox...

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Main Authors: Jannes Spangenberg, Stefan Mündnich, Anne Busch, Stefan Pastore, Anna Wierczeiko, Winfried Goettsch, Vincent Dietrich, Leszek P. Pryszcz, Sonia Cruciani, Eva Maria Novoa, Kandarp Joshi, Ranjan Perera, Salvatore Di Giorgio, Paola Arrubarrena, Irem Tellioglu, Chi-Lam Poon, Yuk Kei Wan, Jonathan Göke, Andreas Hildebrandt, Christoph Dieterich, Mark Helm, Manja Marz, Susanne Gerber, Nicolo Alagna
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01507-0
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https://doi.org/10.1038/s42004-025-01507-0

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