Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice.

Single-cell analysis of gene regulatory networks in the mammary glands of P4HA1-knockout mice.

Prolyl hydroxylation, catalyzed by collagen prolyl 4-hydroxylase (P4H), is a crucial post-translational modification involved in collagen biosynthesis. P4HA1, an isoform of P4H, plays a prominent role in stabilizing hypoxia-inducible factor-1α (HIF-1α). P4HA1 is frequently upregulated in highly aggr...

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Bibliographic Details
Main Authors: Akshat Gupta, Lilin Huang, Jinpeng Liu, Ke Chen, Ren Xu, Wei Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011505
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