Aducanumab delivery via focused ultrasound-induced transient blood–brain barrier opening in vivo

Aducanumab delivery via focused ultrasound-induced transient blood–brain barrier opening in vivo

Abstract Focused ultrasound (FUS) with magnetic resonance imaging (MRI) guidance (MRgFUS) has emerged as a promising technique for enhancing drug delivery to the brain. Through the controlled oscillation of gas-encased microbubbles, FUS temporarily modulates the integrity of tight junctions, inducin...

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Bibliographic Details
Main Authors: Jaeyeong Jeong, Mun Han, Soyeon Jeon, Yejin Kim, Hyo Jin Choi, Woohyuk Choi, Kihyun Kwon, Jong-ryul Choi, Eun-Hee Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Blood–brain barrier
Drug delivery to a brain
Focused ultrasound
Aducanumab
Alzheimer’s disease
Online Access:https://doi.org/10.1038/s41598-025-02412-1
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https://doi.org/10.1038/s41598-025-02412-1

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