Exploration of 1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives effect on triple-negative breast, prostate cancer and melanoma cell 2D and 3D cultures

Exploration of 1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives effect on triple-negative breast, prostate cancer and melanoma cell 2D and 3D cultures

Abstract 1-Substituted 5-oxopyrrolidine-3-carboxylic acid and its derivatives play an important role as components of many biologically active molecules. This study describes the synthesis of 1-(2,4-difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid derivatives and their anticancer properties. The t...

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Bibliographic Details
Main Authors: Guoda Pranaitytė, Birutė Grybaitė, Ugne Endriulaityte, Vytautas Mickevičius, Vilma Petrikaitė
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Azoles
Hydrazones
Triple-negative breast cancer
Prostate carcinoma
Melanoma
Cytotoxicity
Online Access:https://doi.org/10.1038/s41598-025-02106-8
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https://doi.org/10.1038/s41598-025-02106-8

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