CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

CGRPβ suppresses the pathogenesis of ulcerative colitis via the immunoproteasome

Abstract Various factors have been implicated in the pathogenesis of ulcerative colitis (UC), with immune system failure being the most important one. Calcitonin gene-related peptide (CGRP), a neuropeptide with two isoforms, CGRPα and CGRPβ, has been reported to regulate the immune system. In this s...

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Bibliographic Details
Main Authors: Tatsuya Shibao, Hiroaki Hase, Kodai Mizokami, Atsushi Usui, Kaori Kitae, Yuko Ueda, Kentaro Jingushi, Kazutake Tsujikawa
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
CGRP
Ulcerative colitis
Immunoproteasome
Proteomics
Online Access:https://doi.org/10.1038/s41598-025-91933-w
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https://doi.org/10.1038/s41598-025-91933-w

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