Refractory diarrhea in a patient with metastatic breast cancer with ABCB1 polymorphism: A case report

Refractory diarrhea in a patient with metastatic breast cancer with ABCB1 polymorphism: A case report

Although abemaciclib is an essential therapy for breast cancer, approximately 80 % of patients develop diarrhea. Abemaciclib undergoes excretion by the P-glycoprotein encoded by ATP-binding cassette subfamily B member 1 (ABCB1) in the small intestine during absorption. The polymorphism of this gene...

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Main Authors: Moeko Iida, Yoshihiko Tasaki, Akiko Kato, Tomoya Yasujima, Hiroaki Yuasa, Yasuhiro Maeda, Yoshihisa Mimura, Kunihiro Odagiri, Yuka Kimura, Nanami Ito, Yasuhiro Horita, Yosuke Sugiyama, Yuji Hotta, Tatsuya Toyama, Yoko Furukawa-Hibi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Current Problems in Cancer: Case Reports
Subjects:
Abemaciclib
Breast cancer
ABCB1
Case report
Diarrhea
Online Access:http://www.sciencedirect.com/science/article/pii/S2666621925000195
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http://www.sciencedirect.com/science/article/pii/S2666621925000195

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