Model-informed drug development of novel ROCK2 inhibitor TDI01: population pharmacokinetic study and simulation
IntroductionTDI01 is a novel and highly selective ROCK2 inhibitor, which provides a potential valuable candidate for the treatment of ALI/ARDS due to COVID-19.MethodsThe objective of this study was to develop Pop-PK models to characterize the PK properties of TDI, and to guide the choice of suitable...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1477607/full |
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