Copper excess induces autophagy dysfunction and mitochondrial ROS-ferroptosis progression, inhibits cellular biosynthesis of milk protein and lipid in bovine mammary epithelial cells

Copper excess induces autophagy dysfunction and mitochondrial ROS-ferroptosis progression, inhibits cellular biosynthesis of milk protein and lipid in bovine mammary epithelial cells

Excessive copper (Cu) has the potential risk to ecosystems and organism health, with its impact on dairy cow mammary glands being not well-defined. This study used a bovine mammary epithelial cell (MAC-T) model to explore how copper excess affects cellular oxidative stress, autophagy, ferroptosis, a...

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Bibliographic Details
Main Authors: Ya Ting Fan, Dong Qiao Peng, Jing Lin Shen, Jun Hao Cui, Xin Yue Yang, Jin Ge Zhang, Yong Cheng Jin
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Autophagy
Bovine Mammary Epithelial Cell
Copper
Ferroptosis
Milk protein and lipid synthesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325001198
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