Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients
Purpose. To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them. Methods. Sixty diabetic...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2019/3764878 |
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| author | João N. Beato João Esteves-Leandro David Reis Manuel Falcão Vítor Rosas Ângela Carneiro Fernando Falcão Reis |
| author_facet | João N. Beato João Esteves-Leandro David Reis Manuel Falcão Vítor Rosas Ângela Carneiro Fernando Falcão Reis |
| author_sort | João N. Beato |
| collection | DOAJ |
| description | Purpose. To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them. Methods. Sixty diabetic and 48 age- and sex-matched non-DM patients were enrolled in this cross-sectional study. The DM group was analyzed according to DM duration (<or ≥ 10 years), HbA1c levels (<or ≥ 7%), and presence of retinopathy. CH and CRF were evaluated using the Ocular Response Analyzer® (ORA). Central corneal thickness (CCT) was determined by Scheimpflug tomography (Pentacam® HR). Intraocular pressure was obtained with ORA (IOPcc) and Goldmann applanation tonometry (IOP-GAT). Univariate and multivariate linear regression analyses were performed to evaluate the relationship between demographical, clinical, and ocular variables with the biomechanical properties. Results. There were no statistically significant differences in the CH and the CRF between DM and non-DM groups (p=0.637 and p=0.439, respectively). Also, there was no statistical difference between groups for the CCT, IOPcc, or IOP-GAT. Multivariate linear regression analysis showed that CH was positively associated with CCT (p<0.001) and negatively associated with IOPcc (p<0.001), while CRF was positively associated with CCT (p<0.001) and IOPcc (p=0.014). Conclusion. The CCT and IOPcc were found to be the main parameters that affect corneal biomechanical properties both in diabetics and controls. In this study, there was no significant effect of DM type 2 on corneal biomechanics. |
| format | Article |
| id | doaj-art-3ba2e3053a324dee9b7d1522fe0dd227 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3ba2e3053a324dee9b7d1522fe0dd2272025-02-03T06:44:40ZengWileyJournal of Ophthalmology2090-004X2090-00582019-01-01201910.1155/2019/37648783764878Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic PatientsJoão N. Beato0João Esteves-Leandro1David Reis2Manuel Falcão3Vítor Rosas4Ângela Carneiro5Fernando Falcão Reis6Department of Ophthalmology, São João Hospital, Porto, PortugalDepartment of Ophthalmology, São João Hospital, Porto, PortugalFaculty of Medicine, University of Porto, Porto, PortugalDepartment of Ophthalmology, São João Hospital, Porto, PortugalDepartment of Ophthalmology, São João Hospital, Porto, PortugalDepartment of Ophthalmology, São João Hospital, Porto, PortugalDepartment of Ophthalmology, São João Hospital, Porto, PortugalPurpose. To analyze and compare corneal structural and biomechanical properties, characterized by corneal hysteresis (CH) and resistance factor (CRF), between patients with and without type 2 diabetes mellitus (DM), and determine the main ocular variables that influence them. Methods. Sixty diabetic and 48 age- and sex-matched non-DM patients were enrolled in this cross-sectional study. The DM group was analyzed according to DM duration (<or ≥ 10 years), HbA1c levels (<or ≥ 7%), and presence of retinopathy. CH and CRF were evaluated using the Ocular Response Analyzer® (ORA). Central corneal thickness (CCT) was determined by Scheimpflug tomography (Pentacam® HR). Intraocular pressure was obtained with ORA (IOPcc) and Goldmann applanation tonometry (IOP-GAT). Univariate and multivariate linear regression analyses were performed to evaluate the relationship between demographical, clinical, and ocular variables with the biomechanical properties. Results. There were no statistically significant differences in the CH and the CRF between DM and non-DM groups (p=0.637 and p=0.439, respectively). Also, there was no statistical difference between groups for the CCT, IOPcc, or IOP-GAT. Multivariate linear regression analysis showed that CH was positively associated with CCT (p<0.001) and negatively associated with IOPcc (p<0.001), while CRF was positively associated with CCT (p<0.001) and IOPcc (p=0.014). Conclusion. The CCT and IOPcc were found to be the main parameters that affect corneal biomechanical properties both in diabetics and controls. In this study, there was no significant effect of DM type 2 on corneal biomechanics.http://dx.doi.org/10.1155/2019/3764878 |
| spellingShingle | João N. Beato João Esteves-Leandro David Reis Manuel Falcão Vítor Rosas Ângela Carneiro Fernando Falcão Reis Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients Journal of Ophthalmology |
| title | Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients |
| title_full | Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients |
| title_fullStr | Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients |
| title_full_unstemmed | Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients |
| title_short | Structural and Biomechanical Corneal Differences between Type 2 Diabetic and Nondiabetic Patients |
| title_sort | structural and biomechanical corneal differences between type 2 diabetic and nondiabetic patients |
| url | http://dx.doi.org/10.1155/2019/3764878 |
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