Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy

Histone-driven hypercoagulation contributes to the lethal triad of acute trauma-induced coagulopathy

Abstract Severe tissue injury and hemorrhagic shock can result in trauma-induced coagulopathy (TIC), acidosis, and hypothermia, denoted as lethal triad. This condition exacerbates trauma complications and contributes to organ dysfunction and mortality, prompting the need to better define its complex...

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Bibliographic Details
Main Authors: Christian Karl Braun, Marco Mannes, Doreen Tabea Spiegelburg, Frederik Müller, Amadeo Klitzing, Anke Schultze, Andreas Bauer, Gerhard Achatz, Markus Huber-Lang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
TIC
Trauma
Platelets
Hemostasis
Coagulopathy
Online Access:https://doi.org/10.1038/s41598-025-12431-7
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https://doi.org/10.1038/s41598-025-12431-7

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