A lactate-related tSNE signature defines prognostic subtypes of bladder cancer and reveals LINC01094-mediated VIM stabilization in metastasis and drug resistance

A lactate-related tSNE signature defines prognostic subtypes of bladder cancer and reveals LINC01094-mediated VIM stabilization in metastasis and drug resistance

BackgroundBladder cancer (BLCA) is prone to metastasis and often shows poor responses to chemotherapy and immunotherapy. Investigating the underlying mechanisms of metastasis and drug resistance may therefore offer new therapeutic strategies for BLCA.MethodsPublicly available datasets were analyzed...

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Bibliographic Details
Main Authors: Pu Zhang, Hegan Zhang, Wanli Yu, Dage Fan, Yao Pan, Wei Zhuang, Fangzhen Cai, Qingliu He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
bladder cancer
tSNE score
lactate
metastasis
drug resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593523/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593523/full

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