Performance characteristics of a polymerase chain reaction-based assay for the detection of EGFR mutations in plasma cell-free DNA from patients with non-small cell lung cancer using cell-free DNA collection tubes.

Performance characteristics of a polymerase chain reaction-based assay for the detection of EGFR mutations in plasma cell-free DNA from patients with non-small cell lung cancer using cell-free DNA collection tubes.

Survival rates in non-small cell lung cancer (NSCLC) are low. Detection of circulating tumor DNA in liquid biopsy (plasma) is increasingly used to identify targeted therapies for clinically actionable mutations, including EGFR mutations in NSCLC. The cobas® EGFR Mutation Test v2 (cobas EGFR test) is...

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Main Authors: Theresa May, Michelle S Clement, Harkanwal Halait, Alexander Kohlmann, Milena Kohlmann, Jason Lai, Nitta Lee, Xiaocheng Li-Sucholeiki, Peter Meldgaard, Snehal Joshi, Sidney Scudder, Neelima Shrestha, Boe Sorensen, Marilyn Kiral, Patrick O'Donnell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295987&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0295987&type=printable

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