Cycloadditions as a Sweet Route to ‘Double <i>C</i>-Glycosylation’

Cycloadditions as a Sweet Route to ‘Double <i>C</i>-Glycosylation’

Pharmaceuticals, such as the antibiotic erythromycin, and sodium-dependent glucose transporter (SGLT1 & SGTL2) inhibitors such as Bexagliflozin (diabetes) and Sotagliflozin (heart disease), are often sugar-decorated (glycosylated). Glycosylation is a key component of the binding motif in SGLT in...

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Bibliographic Details
Main Authors: Kevin P. P. Mahoney, Rosemary Lynch, Rhea T. Bown, Sunil V. Sharma, Piyasiri Chueakwon, G. Richard Stephenson, David B. Cordes, Alexandra M. Z. Slawin, Rebecca J. M. Goss
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomolecules
Subjects:
cycloaddition
biomimetic
granaticin
natural product analogue
Online Access:https://www.mdpi.com/2218-273X/15/6/905
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