Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation

Endogenous chondroitin extends lifespan by inhibiting VHA-7-mediated tubular lysosome formation

Abstract Chondroitin extends lifespan and healthspan in C. elegans, but the relationship between extracellular chondroitin and intracellular anti-aging mechanisms is unknown. The basement membrane (BM) that contains chondroitin proteoglycans is anchored to cells via hemidesmosomes (HDs), and it accu...

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Main Authors: Yukimasa Shibata, Yuri Tanaka, Shunsuke Mori, Kaito Mitsuzumi, Shion Fujii, Hiroyuki Sasakura, Yuki Morioka, Kenji Sugioka, Kosei Takeuchi, Kiyoji Nishiwaki
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Aging
Chondroitin
Hemidesmosomes
Tubular lysosomes
Basement membrane
Online Access:https://doi.org/10.1038/s41598-024-80242-3
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https://doi.org/10.1038/s41598-024-80242-3

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