DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

DNA methylation inhibitor attenuates polyglutamine‐induced neurodegeneration by regulating Hes5

Abstract Spinal and bulbar muscular atrophy (SBMA) is a polyglutamine‐mediated neuromuscular disease caused by a CAG repeat expansion in the androgen receptor (AR) gene. While transcriptional dysregulation is known to play a critical role in the pathogenesis of SBMA, the underlying molecular pathome...

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Bibliographic Details
Main Authors: Naohide Kondo, Genki Tohnai, Kentaro Sahashi, Madoka Iida, Mayumi Kataoka, Hideaki Nakatsuji, Yutaka Tsutsumi, Atsushi Hashizume, Hiroaki Adachi, Haruki Koike, Keiko Shinjo, Yutaka Kondo, Gen Sobue, Masahisa Katsuno
Format: Article
Language:English
Published: Springer Nature 2019-04-01
Series:EMBO Molecular Medicine
Subjects:
DNA methylation
epigenetics
Hes5
RG108
spinal and bulbar muscular atrophy
Online Access:https://doi.org/10.15252/emmm.201708547
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https://doi.org/10.15252/emmm.201708547

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