Challenges and Insights in Absolute Quantification of Recombinant Therapeutic Antibodies by Mass Spectrometry: An Introductory Review

Challenges and Insights in Absolute Quantification of Recombinant Therapeutic Antibodies by Mass Spectrometry: An Introductory Review

This review describes mass spectrometry (MS)-based approaches for the absolute quantification of therapeutic monoclonal antibodies (mAbs), focusing on technical challenges in sample treatment and calibration. Therapeutic mAbs are crucial for treating cancer and inflammatory, infectious, and autoimmu...

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Bibliographic Details
Main Authors: Sarah Döring, Michael G. Weller, Yvonne Reinders, Zoltán Konthur, Carsten Jaeger
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antibodies
Subjects:
monoclonal antibody
therapeutic antibodies
mass spectrometry
liquid chromatography
absolute quantification
isotope labeling
Online Access:https://www.mdpi.com/2073-4468/14/1/3
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