Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial

Standard versus double dosing of beta-lactam antibiotics in critically ill patients with sepsis: The BULLSEYE study protocol for a multicenter randomized controlled trial

Abstract Background Sepsis and septic shock are significant global healthcare challenges with high mortality rates. Effective management requires timely and adequate antimicrobial therapy. Beta-lactam antibiotics, commonly used in patients with sepsis, are crucial for treating these infections. Howe...

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Main Authors: M. M. B. Horstink, D. R. Geel, C. A. den Uil, P. E. Deetman, H. Endeman, A. Abdulla, T. M. Bosch, W. J. R. Rietdijk, F. W. Thielen, J. J. Haringman, P. van Vliet, T. A. Rijpstra, C. Bethlehem, A. Beishuizen, A. E. Muller, B. C. P. Koch, on behalf of The BULLSEYE investigators
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Infectious Diseases
Subjects:
Sepsis
Beta-lactam
Antibiotics
Critically ill
Intensive care
Randomized controlled trial
Online Access:https://doi.org/10.1186/s12879-025-10747-3
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https://doi.org/10.1186/s12879-025-10747-3

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