Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression

Modulation of senescent Lepr+ skeletal stem cells via suppression of leptin-induced STAT3‒FGF7 axis activation alleviates abnormal subchondral bone remodeling and osteoarthritis progression

Abstract Background Recent studies have suggested that targeting senescent cells in joint tissues may alleviate osteoarthritis (OA) progression. However, this strategy encounters significant challenges, partially due to the high degree of cellular heterogeneity in osteoarthritic tissues. Moreover, l...

Full description

Saved in:
Bibliographic Details
Main Authors: Fu-Hao Yu, Bo-Feng Yin, Ming-Yu Liu, Wen-Jing Zhang, Zhi-Dong Zhao, Lei Wang, Xiao-Tong Li, Pei-Lin Li, Zhi-Ling Li, Run-Xiang Xu, Li Ding, Heng Zhu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Stem Cell Research & Therapy
Subjects:
Osteoarthritis
Single-cell sequencing
Skeletal stem cells
Heterogeneity of Cellular senescence
Leptin-Lepr signaling
STAT3-FGF7 axis
Online Access:https://doi.org/10.1186/s13287-025-04342-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13287-025-04342-1

Similar Items