Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome

Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome

Abstract INTRODUCTION Both micro‐ and macrostructural white matter (WM) abnormalities, particularly those related to axonal degeneration, are associated with cognitive decline in adults with Down syndrome (DS) prior to a diagnosis of Alzheimer disease. Neurofilament light chain (NfL) is a support pr...

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Main Authors: Herminia Diana Rosas, Nathaniel David Mercaldo, Yasemin Hasimoglu, Melissa Petersen, Lydia R. Lewis, Florence Lai, David Powell, Asim Dhungana, Ali Demir, David Keater, Michael Yassa, Adam M. Brickman, Sid O'Bryant
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Subjects:
Alzheimer's disease
diffusion weighted imaging
Down syndrome
white matter microstructural integrity
Online Access:https://doi.org/10.1002/dad2.70023
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https://doi.org/10.1002/dad2.70023

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