Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Lipid metabolism reprograming by SREBP1‐PCSK9 targeting sensitizes pancreatic cancer to immunochemotherapy

Abstract Background Pancreatic cancer's aberrant lipid metabolism fuels cell growth, invasion, and metastasis, yet its impact on immune surveillance and immunotherapy is unclear. This study investigated how sterol regulatory element‐binding transcription factor 1 (SREBP1)‐driven lipid metabolis...

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Main Authors: Mengyi Lao, Xiaozhen Zhang, Zejun Li, Kang Sun, Hanshen Yang, Sicheng Wang, Lihong He, Yan Chen, Hanjia Zhang, Jiatao Shi, Daqian Xu, Tingbo Liang, Xueli Bai
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Cancer Communications
Subjects:
Pancreatic ductal adenocarcinoma
lipid metabolism
immunochemotherapy
SREBP1
PCSK9
immunosuppressive tumor microenvironment
Online Access:https://doi.org/10.1002/cac2.70038
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https://doi.org/10.1002/cac2.70038

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