Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial

Rationale and design of ‘discontinuing statins in multimorbid older adults without cardiovascular disease (STREAM)’: study protocol of a randomised non-inferiority clinical trial

Introduction Statins are among the most widely used drugs. While they are effective for primary and secondary prevention of cardiovascular (CV) disease in middle-aged subjects, their benefits for prevention in older adults (aged ≥70 years) without CV disease are uncertain, particularly for those wit...

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Main Authors: Mirjam Christ-Crain, Manuel R Blum, Philipp Schuetz, Luise Adam, Elisavet Moutzouri, Martin Feller, Drahomir Aujesky, Sven Trelle, Nicolas Rodondi, Marie Méan, Rosalinde K E Poortvliet, Jürg-Hans Beer, Stefano Bassetti, Fabrice Bonnet, Sebastian Carballo, Baris Gencer, Robert Escher, Dina Zekry, Maria M Wertli, Luca Gabutti, Philipp Stefan Aebi, Moa Haller, Julia Bianca Bardoczi, Alan G Haynes, Patricia Orializ Chocano-Bedoya, Martin Egger, Douglas Bauer
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/5/e093833.full
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